Although smaller in size compared to other Jewish communities in Greece, the Jewish Community of Trikala was historically particularly significant. With a presence dating back to the Byzantine period and strengthened after 1492, the community developed intense religious, commercial, and social activity. The Jews of Trikala had their own neighborhoods, synagogues, and schools, and excelled in trade, especially in textiles and leather. During the Occupation, the Italians initially protected the city’s Jews; however, the persecutions began with the arrival of the Germans. Nevertheless, the community recorded one of the lowest loss rates compared to other Greek cities. Today, its historic Synagogue, renovated, keeps alive the memory of the centuries-old Jewish presence in the city.